Rats were given different treatment as female rats respectively. 30 male rats aged 10 weeks or 72 weeks were dived into 3 groups respectively, 10 in each group. Rats in the control group were given tap water, the β-alanine group was given water containing 1%β-alanine, and the taurine group was given water containing 1% taurine. Female rats were given different water from the day of confinement which was defined as the first day of the newborn rats. 15 pregnant rats with the similar expected confinement date were divided into three groups randomly, five in each group. Impregnation was determined if sperm were detected on the second day. After acclimatizing for 1 week, all rats were used in the experiment.įemale rats were put together with male rats in cages after the oestrus of female rats were determined by vaginal smear. They were maintained in controlled light (14h-light, 10h-dark) and temperature (22☒☌), and were given free access to rat chow and water. Male rats were 10 (adult) and 72 (aged) weeks old, female rats were 10 weeks old (about 200 g). The correlation between the decline of taurine content and aged male reproduction was also evaluated in the present study.Īll Wistar rats were obtained from the central animal house of the Chinese Medical University. However, a number of studies have reported that the concentration of taurine is obviously decreased in serum and some tissues of aged animals. It is well known that aging results in a significant decline in male reproduction. The primary aim of the present study was to further investigate the effect of taurine on male reproduction in rats. Despite its importance, the effect of taurine on the male reproduction is still unclear. Our laboratory had previously reported that taurine can stimulate testosterone secretion in vivo and in vitro. Taurine may act as an antioxidant, capacitating agent, membrane-stabilized factor and motility factor of sperm. In addition, taurine has been identified as the major free amino acid of sperm cells and seminal fluid. It has also been reported that taurine can be biosynthesized by male reproductive organs. In the male reproductive system, taurine has been detected in Leydig cells, vascular endothelial cells, and some other interstitial cells of testis and epithelial cells of efferent ducts in rats. However, several physiological functions of taurine have been demonstrated, such as osmoregulation, calcium modulation, membrane stabilization, antioxidation, radioprotection, energy storage, xenobiotic conjugation, isethionic acid and anion balance et al.Īs a semi-essential amino acid, taurine is rich in many tissues, and can be biosynthesized by many tissues, such as the central nervous system, liver, kidney, retina and mammary gland. Taurine is not involved in protein synthesis or in metabolic pathway. Taurine, 2-aminoethane sulphonic acid, is one of the most abundant low-molecular-weight organic constituents in human and many animals.
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